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Motoko Sasaki Selected Research

Cyclin-Dependent Kinase Inhibitor p16

9/2016Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis.
3/2014Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma.
2/2013Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct.
7/2011Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease.
2/2010Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma.
2/2010Bile ductular cells undergoing cellular senescence increase in chronic liver diseases along with fibrous progression.
10/2009Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts.
8/2008Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study.
7/2008Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence.

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Motoko Sasaki Research Topics

Disease

47Neoplasms (Cancer)
11/2020 - 10/2003
35Cholangiocarcinoma
11/2020 - 02/2003
24Carcinoma (Carcinomatosis)
01/2020 - 02/2003
18Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
01/2021 - 06/2002
11Carcinogenesis
06/2016 - 02/2006
9Cholangitis
01/2017 - 06/2002
9Adenocarcinoma
01/2014 - 02/2006
8Hepatocellular Carcinoma (Hepatoma)
11/2016 - 08/2008
8Fibrosis (Cirrhosis)
09/2016 - 12/2003
6Hepatitis
10/2014 - 07/2009
6Non-alcoholic Fatty Liver Disease
07/2011 - 04/2007
5Liver Cirrhosis (Hepatic Cirrhosis)
04/2018 - 10/2006
5Inflammation (Inflammations)
04/2014 - 08/2002
5Carcinoma in Situ
01/2014 - 12/2004
4Liver Cell Adenoma (Hepatocellular Adenoma)
11/2016 - 11/2012
4Focal Nodular Hyperplasia
11/2016 - 02/2009
4Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis)
05/2015 - 01/2012
4Sclerosing Cholangitis
06/2014 - 07/2003
4Metaplasia
12/2012 - 05/2004
4Neoplasm Metastasis (Metastasis)
10/2009 - 04/2006
3Necrosis
08/2020 - 02/2009
3Cysts
10/2018 - 10/2006
3Hyperplasia
11/2016 - 02/2009
3Idiopathic Noncirrhotic Portal Hypertension
12/2015 - 08/2007
3Pancreatic Neoplasms (Pancreatic Cancer)
02/2015 - 08/2012
3Neoplasms, Cystic, Mucinous, and Serous
01/2014 - 12/2012
3Polycystic Kidney Diseases (Polycystic Kidney Disease)
12/2011 - 10/2006
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2010 - 01/2002
3Mucinous Adenocarcinoma (Mucinous Carcinoma)
05/2010 - 02/2006
2Caroli Disease (Caroli's Disease)
08/2021 - 10/2018
2Liver Failure
04/2018 - 12/2007
2Alcoholic Liver Diseases (Alcoholic Liver Disease)
02/2017 - 09/2015
2Endodermal Sinus Tumor (Endodermal Sinus Tumors)
01/2014 - 11/2012
2Klatskin Tumor
08/2013 - 05/2013
2Eosinophilia
08/2011 - 06/2005
2Adenoma (Adenomas)
07/2010 - 03/2009
2Liver Diseases (Liver Disease)
02/2010 - 01/2010
2Digestive System Diseases
01/2007 - 07/2003
1Congenital Hepatic Fibrosis
08/2021
1Polycystic liver disease
08/2021
1Lung Neoplasms (Lung Cancer)
10/2020
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2020

Drug/Important Bio-Agent (IBA)

15Bile Pigments (Bilin)IBA
06/2016 - 04/2005
13MucinsIBA
02/2014 - 10/2002
12Proteins (Proteins, Gene)FDA Link
01/2021 - 07/2003
9Cyclin-Dependent Kinase Inhibitor p16IBA
09/2016 - 07/2008
6Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)IBA
06/2018 - 04/2008
6Polycomb-Group ProteinsIBA
03/2015 - 08/2008
5Biological ProductsIBA
01/2020 - 01/2007
5Serum Amyloid A Protein (Serum Amyloid A)IBA
09/2015 - 01/2012
5Transforming Growth Factor beta1 (TGF beta 1)IBA
07/2010 - 04/2005
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2009 - 04/2006
4Cyclin D1IBA
10/2018 - 12/2004
4AntigensIBA
01/2018 - 06/2002
4AntibodiesIBA
01/2017 - 06/2002
4Biomarkers (Surrogate Marker)IBA
10/2014 - 01/2012
4Small Interfering RNA (siRNA)IBA
02/2013 - 12/2009
4Keratins (Keratin)IBA
02/2011 - 04/2007
4Cadherins (E-Cadherin)IBA
05/2010 - 11/2007
3EnzymesIBA
10/2018 - 03/2009
3Messenger RNA (mRNA)IBA
01/2017 - 03/2004
3gadolinium ethoxybenzyl DTPAFDA Link
11/2016 - 11/2012
3Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA
12/2015 - 12/2012
3Mitochondrial Proteins (Mitochondrial Protein)IBA
10/2015 - 02/2013
3GlypicansIBA
05/2015 - 11/2012
3Immunoglobulin G (IgG)IBA
04/2014 - 06/2005
3Transcription Factors (Transcription Factor)IBA
05/2013 - 10/2008
3Keratin-7 (Cytokeratin 7)IBA
12/2012 - 02/2003
3beta CateninIBA
11/2012 - 11/2007
3Matrix Metalloproteinase 14 (MT1-MMP)IBA
11/2010 - 05/2008
3Reactive Oxygen Species (Oxygen Radicals)IBA
02/2010 - 08/2002
3beta-Galactosidase (Lactaid)IBA
07/2009 - 03/2005
3CytokinesIBA
10/2008 - 12/2003
2ErbB Receptors (EGF Receptor)IBA
10/2020 - 10/2006
2Tyrosine Kinase InhibitorsIBA
10/2020 - 10/2006
2Amiodarone (Amiodarona)FDA LinkGeneric
08/2020 - 04/2018
2Antinuclear AntibodiesIBA
08/2019 - 11/2007
2Fetal Proteins (Fetoprotein)IBA
02/2017 - 11/2012
2Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA
01/2017 - 06/2002
2ChemokinesIBA
02/2014 - 07/2011
2Phenobarbital (Luminal)FDA Link
05/2013 - 08/2002
2AutoantibodiesIBA
01/2012 - 01/2010
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2011 - 02/2009
2CateninsIBA
10/2011 - 10/2009
2Insulin (Novolin)FDA Link
02/2010 - 11/2007
2Matrix Metalloproteinase 9 (Gelatinase B)IBA
03/2009 - 02/2009
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
03/2009 - 01/2003
2NF-kappa B (NF-kB)IBA
02/2009 - 06/2007
2Scavenger Receptors (Scavenger Receptor)IBA
10/2007 - 08/2002
2Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2007 - 03/2005
2Trefoil FactorsIBA
01/2007 - 10/2003
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2006 - 01/2003
11-dodecylpyridoxal (PLD)IBA
08/2021
1InterferonsIBA
01/2021
1Granzymes (Granzyme)IBA
11/2020
1Immune Checkpoint InhibitorsIBA
11/2020
1Erlotinib Hydrochloride (CP 358,774)FDA Link
10/2020

Therapy/Procedure

5Therapeutics
11/2020 - 04/2006
3Drug Therapy (Chemotherapy)
06/2019 - 01/2014
3Hepatectomy
10/2014 - 12/2007